Oral Manifestations of Pediatric Human Immunodeficiency Virus Infection: A Review of the Literature

Dan Boboia 2/26/10 Lit. Review

Title: Oral Manifestations of Pediatric Human Immunodeficiency Virus Infection: A Review of the Literature
Author: Kline et al
Type of Article: Review

Purpose: To describe the varied oral manifestations of pediatric HIV infections

Erythematous Candidiasis: inconspicous erythematous changes of the palate and dorsum of the tonugue; buccal mucosa involved occasionally; vesicles seen in severe cases; more common among children with low CD4 lymphocyte counts or symptomatic HIV disease than among those with normal counts or no symptoms.

Hairy Luekoplakia: white or gray lesions along the lateral margins of the tongue; lesions appear hairy when affected mucosa is dried; not specific for HIV infection but common for profound immunosuppresion; related to presence of EBV within the oral mucosal epithelium.

Oral Kaposi’s Sarcoma: blue, purple, or red flat or raised patches / nodules, often involving the palate.

Periodontal Disease: several forms of perio are associated with HIV infection; linear gingival erythema has fiery red band along the margin of the gingival; necritizing ulcerative gingivitis show destruction of one or more of the interdental papillae.

Oral Ulcers: lesions often are severely debilitating because they interfere with chewing, speaking, and swallowing.

Cytomeglovirus: another herpes group virus, cam produce large palatal or pharyngeal ulcers resembling major aphthous ulcers as well as changes resemble HIV-associated periodontal disease

Non-Hodgkins lymphoma: is the other form of malignancy diagnosed commonly in adults with AIDS