Resident: Roberts
Date: 4/16/10
Article title: Generalized prepubertal periodontitis
Author: Gurel, et al
Journal: Journal of Clinical Periodontology
Volume: 23, pages: 1104-1111
Year: 1996
Discussions
Generalized prepubertal peridontitis is a rare clinical entity characterized by acute inflammation and proliferation of the ginigiva with rapid destruction of the alveolar bone.
4 cases were presented in this article. All of which had a decrease in peripheral blood nertrophil chemotaxis. Peripheral blood lymphocyte subpopulations were analyzed by double – colored flow cytometetry using monoclonal antibodies for the receptors CD2, CD3, CD4, CD8, CD19, CD29, CD45RA, CD56, CD11bCD18. Lymphocytes bearing CD3 receptors showed a significant decrease compared to those of the controls. Natural Killer cells were lowered in 3 of the 4 cases. All of the patients showed a higher increase in CD11bCD18 expression. The evaluation of CD11bCD18 receptor in peripheral blood leukocytes may be of help explaining the role of neutrophils in the pathogenesis of the disease.
Assessment: An okay artcle, I wish there was more information on the disease and less of the actual biochemistry.
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