Resident’s Name: Joanne Lewis Date: January 22, 2010
Article title: Chemoradiation therapy: effect on dental development
Author(s): Curt Goho, DDS
Journal: Pediatric Dentistry: Jan/Feb 1993 – Volume 15, Number 1
Type of Article: Scientific article
Main Purpose: to provide an overview of the effects of chemoradiation therapy on dental development.
Key points/Summary: Radiation – sufficiently high radiation doses cause ameloblast and ondontoblast death – can result in complete tooth agenesis; partially formed teeth have remaining development halted, with tooth and/or root agenesis. Lower radiation doses cause sublethal changes; odontoblasts are most susceptible to low-dose radiation just before initiating dentin matrix formation => localized dental defects seen as niches in the dentin or wavy, irregular dentinoenamel junction, with enamel hypoplasias over the defective dentin and shortened, thin, tapered roots. Chemotherapy – can easily damage odontoblasts and ameloblasts that are in susceptible phases of the cell cycle (M or S) => tooth agenesis, thin, tapered roots.
Assessment of article: Good article – very interesting.
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